WebDental

Social network for dentists and dental professionals to share news and ideas.

DNA Vaccines Show Promise in Preventing Dental Decay

In a report on a preclinical investigation titled "Flagellin Enhances Saliva Ig A Response and Protection of Anti-caries DNA Vaccine," lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines.

This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.

Furthermore, Shi found that enhanced surface protein immunoglobulin A responses in saliva were associated with inhibition of S. mutans colonization of tooth surfaces and endowed better protection with significant less carious lesions. In conclusion, the study demonstrates that recombinant Salmonella could enhance specific immunoglobulin A responses in saliva and protective ability of pGJA-P/VAX, providing an effective mucosal adjuvant candidate for intranasal immunization of an anti-caries DNA vaccine.

Daniel Smith, The Forsyth Institute, wrote a corresponding perspective article in response to the Shi et al report titled "Prospects in Caries Vaccine Development." In it, he states that DNA vaccine approaches for dental caries have had a history of success in animal models. Dental caries vaccines, directed to key components of S. mutans colonization and enhanced by safe and effective adjuvants and optimal delivery vehicles, are likely to be forthcoming.

"These papers highlight the exciting potential of using vaccines to protect against dental caries," said JDR Editor-in-Chief William Giannobile. "This research is promising and provides optimism to help promote public health of caries-susceptible individuals."

 

Source:  Science Daily

Journal Reference:

  1. W. Shi, Y. H. Li, F. Liu, J. Y. Yang, D. H. Zhou, Y. Q. Chen, Y. Zhang, Y. Yang, B. X. He, C. Han, M. W. Fan, H. M. Yan. Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine. Journal of Dental Research, Published online Oct. 25, 2011 DOI: 10.1177/0022034511424283

 

Views: 452

Tags: caries, decay, dental, mutans, prevention, steptociccus, tooth, vaccine

Comment

You need to be a member of WebDental to add comments!

Join WebDental

WebDental Facebook Fan Page

Latest Activity

Tariq Drabu posted a status
""Tips on Getting Comfortable with Your New Dentures" Read full Article>>http://bit.ly/1Flv2br"
10 hours ago
Dr. Ted Rothstein DDS PhD left a comment for Umesh Chauhan
"A beautiful smile is a priceless asset that that gives you confidence and joy each time you see…"
yesterday
Umesh Chauhan left a comment for Dr. Ted Rothstein DDS PhD
"Be Happy"
yesterday
Umesh Chauhan left a comment for Daniel G. Egli
"Be Happy"
yesterday
Profile IconDr. Ted Rothstein DDS PhD, Daniel G. Egli and Marion Tusalem joined WebDental
yesterday
Tariq Drabu posted a status
""Thinking of Dental Implants – What You Need to Know" Read full Article>>http://bit.ly/1Dj7hLa"
yesterday
Marion Tusalem left a comment for Umesh Chauhan
"Thank you Umesh and pleasant to meet you!"
yesterday
Umesh Chauhan left a comment for Hiten Pabari
"Be Happy"
yesterday

© 2015   Created by WebDental.

Badges  |  Report an Issue  |  Terms of Service