WebDental

Social network for dentists and dental professionals to share news and ideas.

DNA Vaccines Show Promise in Preventing Dental Decay

In a report on a preclinical investigation titled "Flagellin Enhances Saliva Ig A Response and Protection of Anti-caries DNA Vaccine," lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines.

This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.

Furthermore, Shi found that enhanced surface protein immunoglobulin A responses in saliva were associated with inhibition of S. mutans colonization of tooth surfaces and endowed better protection with significant less carious lesions. In conclusion, the study demonstrates that recombinant Salmonella could enhance specific immunoglobulin A responses in saliva and protective ability of pGJA-P/VAX, providing an effective mucosal adjuvant candidate for intranasal immunization of an anti-caries DNA vaccine.

Daniel Smith, The Forsyth Institute, wrote a corresponding perspective article in response to the Shi et al report titled "Prospects in Caries Vaccine Development." In it, he states that DNA vaccine approaches for dental caries have had a history of success in animal models. Dental caries vaccines, directed to key components of S. mutans colonization and enhanced by safe and effective adjuvants and optimal delivery vehicles, are likely to be forthcoming.

"These papers highlight the exciting potential of using vaccines to protect against dental caries," said JDR Editor-in-Chief William Giannobile. "This research is promising and provides optimism to help promote public health of caries-susceptible individuals."

 

Source:  Science Daily

Journal Reference:

  1. W. Shi, Y. H. Li, F. Liu, J. Y. Yang, D. H. Zhou, Y. Q. Chen, Y. Zhang, Y. Yang, B. X. He, C. Han, M. W. Fan, H. M. Yan. Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine. Journal of Dental Research, Published online Oct. 25, 2011 DOI: 10.1177/0022034511424283

 

Views: 436

Tags: caries, decay, dental, mutans, prevention, steptociccus, tooth, vaccine

Comment

You need to be a member of WebDental to add comments!

Join WebDental

WebDental Facebook Fan Page

Latest Activity

Meera Dental Hospital is now a member of WebDental
6 hours ago
Indian dental academy left a comment for shweta
"Dear Doctor, Indian Dental Academy is a Leader in Continuing Dental Education. Offers Training in Fixed Orthodontics, Implant Dentistry, Laser Dentistry, Cosmetic Dentistry & Many more. Having the best Infra structure & world wide reputed…"
yesterday
Richard Elias updated their profile
Monday
Adonia Dennis posted a blog post

Your teeth and aging- How aging can affect your teeth

Teeth and aging overviewNo one is exempt from practicing proper oral health care.  Whether you’re young or old, it pays to have a good set of teeth and healthy gums not only to keep you looking youthful but, more importantly, to help keep you healthy.One of the biggest misconceptions about aging is that it automatically comes…See More
Monday
Indian dental academy left a comment for Sohail Amar
"Dear Doctor, The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses  in different…"
Monday
Indian dental academy joined WebDental's group
Thumbnail

Periodontics

Network, communicate, and post questions regarding treatment of periodontal disease.
Monday
Stephen A Hassler updated their profile
Sunday
Indian dental academy joined WebDental's group
Thumbnail

Implant Dentistry

Network with colleagues and post questions to experts regarding the very latest in dental implant treatment.
Saturday

© 2014   Created by WebDental.

Badges  |  Report an Issue  |  Terms of Service