WebDental

Social network for dentists and dental professionals to share news and ideas.

DNA Vaccines Show Promise in Preventing Dental Decay

In a report on a preclinical investigation titled "Flagellin Enhances Saliva Ig A Response and Protection of Anti-caries DNA Vaccine," lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines.

This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.

Furthermore, Shi found that enhanced surface protein immunoglobulin A responses in saliva were associated with inhibition of S. mutans colonization of tooth surfaces and endowed better protection with significant less carious lesions. In conclusion, the study demonstrates that recombinant Salmonella could enhance specific immunoglobulin A responses in saliva and protective ability of pGJA-P/VAX, providing an effective mucosal adjuvant candidate for intranasal immunization of an anti-caries DNA vaccine.

Daniel Smith, The Forsyth Institute, wrote a corresponding perspective article in response to the Shi et al report titled "Prospects in Caries Vaccine Development." In it, he states that DNA vaccine approaches for dental caries have had a history of success in animal models. Dental caries vaccines, directed to key components of S. mutans colonization and enhanced by safe and effective adjuvants and optimal delivery vehicles, are likely to be forthcoming.

"These papers highlight the exciting potential of using vaccines to protect against dental caries," said JDR Editor-in-Chief William Giannobile. "This research is promising and provides optimism to help promote public health of caries-susceptible individuals."

 

Source:  Science Daily

Journal Reference:

  1. W. Shi, Y. H. Li, F. Liu, J. Y. Yang, D. H. Zhou, Y. Q. Chen, Y. Zhang, Y. Yang, B. X. He, C. Han, M. W. Fan, H. M. Yan. Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine. Journal of Dental Research, Published online Oct. 25, 2011 DOI: 10.1177/0022034511424283

 

Views: 483

Comment

You need to be a member of WebDental to add comments!

Join WebDental

WebDental Facebook Fan Page

Latest Activity

Andrew N. Bitter posted an event

Free Teeth Whitening for new patients at Oxford Dental Care

May 27, 2016 at 6pm to December 31, 2016 at 7pm
Get free custom bleach trays from…See More
yesterday
Dr. Steffany Mohan commented on theddsnetwork.com's blog post Advice For Preventing Tooth Decay
" Great advice you have given for preventing tooth decay. Many factors can cause tooth enamel…"
yesterday
Dr. Steffany Mohan commented on theddsnetwork.com's blog post How to Clean Your Teeth Properly While Preventing Dental Damage
"You pose an excellent question. Ideas and tips are really effective and helpful. Your home care…"
Thursday
Dr. Steffany Mohan left a comment for Rai Mirrow
"Hi, dropping by to say hello. This is Plaza Dental Group, one of the best leading dentists in and…"
Thursday
Saba Singh posted a video

2 Best Natural Home Remedies For TOOTH DECAY TREATMENT

CHECK OUT the common causes, symptoms & treatments of TOOTH DECAY. LEARN best home based cure to tooth decay. Tooth Decay is the most common problem. We have...
Wednesday
Profile IconCARL COLAIZZI and Smilesbylyles Orthodontics joined WebDental
Wednesday
Imagination Dental Solutions updated their profile
Tuesday
Dr. Steffany Mohan commented on Steve Mangan's blog post Is Cosmetic Dentistry Worth all the Time and Money spent on it?
"You have done all works very carefully. Yes, Dentistry is continually evolving, and with a variety…"
Tuesday

© 2016   Created by WebDental.   Powered by

Badges  |  Report an Issue  |  Terms of Service